Yoon Soo Jin, Lee Hong Soo, Lee Sang Wha, Yun Ji Eun, Kim Sang Yon, Cho Eo Rin, Lee Sun Ju, Jee Eun Jung, Lee Hee Yeon, Park Jungyong, Kim Hyon-Suk, Jee Sun Ha
Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Metabolism. 2008 Jun;57(6):853-7. doi: 10.1016/j.metabol.2008.01.031.
As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes.
作为肥胖的指标，腰围（WC）、体重指数（BMI）和脂联素是众所周知的糖尿病危险因素。本研究的目的是测量这些肥胖指标与糖尿病之间的独立关联，并检验这些指标对韩国人群糖尿病的综合影响。对4459名健康韩国人测量了WC、BMI和血清脂联素，并将其分为男性和女性的三分位数组。使用逻辑回归分析测量肥胖指标与糖尿病的独立和综合关联。糖尿病定义为空腹血清葡萄糖大于126mg/dL或正在服药。脂联素水平与BMI和WC呈负相关，与年龄和高密度脂蛋白（HDL）胆固醇呈正相关（P<.001）。在调整年龄、BMI、WC和其他生活方式因素后，低水平的脂联素与糖尿病患病率增加有关。进一步调整HDL胆固醇和甘油三酯后，这种关联在女性中减弱，但在男性中未减弱。WC和脂联素对糖尿病的综合影响逐渐增加；然而，这两个变量之间的相互作用在统计学上并不显著。BMI和脂联素对糖尿病的综合影响显示出类似的结果。这些结果表明脂联素与糖尿病有关。这种关联独立于BMI和WC，部分受HDL和甘油三酯的影响。脂联素与WC和BMI对糖尿病没有效应修饰作用。
