Giordano Thomas J
Department of Pathology, 1150 West Medical Center Drive, MSRB-2, C570D, University of Michigan Health System, Ann Arbor, MI 48109, USA.
Endocrinol Metab Clin North Am. 2008 Jun;37(2):311-31, vii-viii. doi: 10.1016/j.ecl.2007.12.005.
There is much interest in the application of genome biology to the field of thyroid neoplasia, despite the relatively low mortality rate associated with thyroid cancer in general. The principal reason for this interest is that the field of thyroid neoplasia stands to benefit from the application of genomic information to address a variety of pathologic and clinical issues. In addition to practical patient care issues, there is an excellent opportunity of expand the basic understanding of thyroid carcinogenesis. In this article, the most relevant genomic work on thyroid tumors performed to date is reviewed along with some general comments about the potential impact of genomic biology on thyroid pathology and the management of patients with thyroid nodules and cancer.
尽管甲状腺癌总体死亡率相对较低，但基因组生物学在甲状腺肿瘤领域的应用仍备受关注。这种关注的主要原因在于，甲状腺肿瘤领域有望借助基因组信息的应用来解决各种病理和临床问题。除了实际的患者护理问题外，还有绝佳的机会来拓展对甲状腺癌发生机制的基础认识。在本文中，我们回顾了迄今为止进行的与甲状腺肿瘤最相关的基因组研究工作，并对基因组生物学对甲状腺病理学以及甲状腺结节和癌症患者管理的潜在影响作了一些一般性评论。
