Sener Mesut, Bilen Ahmet, Bozdogan Nesrin, Kilic Dalokay, Arslan Gulnaz
Department of Anesthesiology and Reanimation, Baskent University Faculty of Medicine, Ankara, Turkey.
J Clin Anesth. 2008 May;20(3):206-9. doi: 10.1016/j.jclinane.2007.07.009.
Myasthenia gravis is a chronic autoimmune disease characterized by a reduction of postsynaptic nicotinic acetylcholine receptors at the neuromuscular junction. Most myasthenia gravis patients require thymectomy. Intravenous (IV) anesthetics may be superior to inhalation agents in these patients. The Laryngeal Mask Airway (LMA), when compared with the endotracheal tube, causes less airway resistance, which in turn may lead to a decreased bronchoconstrictive reflex, less atelectasis, and fewer pulmonary infections. We report 5 patients with myasthenia gravis, who underwent transsternal thymectomy with total IV anesthesia and LMA.
重症肌无力是一种慢性自身免疫性疾病，其特征是神经肌肉接头处突触后烟碱型乙酰胆碱受体减少。大多数重症肌无力患者需要进行胸腺切除术。在这些患者中，静脉麻醉剂可能优于吸入麻醉剂。与气管内导管相比，喉罩气道产生的气道阻力较小，这反过来可能导致支气管收缩反射减弱、肺不张减少和肺部感染减少。我们报告了5例重症肌无力患者，他们在全凭静脉麻醉和喉罩气道下接受了经胸骨胸腺切除术。
