环磷酸腺苷引发的豚鼠肝细胞内[Ca2+]的振荡
Cyclic AMP-evoked oscillations of intracellular [Ca2+] in guinea-pig hepatocytes.
作者信息
Capiod T, Noel J, Combettes L, Claret M
机构信息
INSERM U274, Université Paris-Sud, Orsay, France.
出版信息
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):277-80. doi: 10.1042/bj2750277.
Abstract
The effects of the beta-adrenoceptor agonist isoprenaline and cyclic AMP (cAMP) on cytosolic free Ca2+ ([Ca2+]i) were studied in the single guinea-pig hepatocyte. In common with InsP3-dependent agonists such as noradrenaline or angiotensin II, isoprenaline (0.5-10 microM) and cAMP (50-100 mM, perfused into the cell via the patch-pipette), were able to generate fast and slow fluctuations of [Ca2+]i. Responses to isoprenaline and cAMP also were observed in the absence of external Ca2+. Isoprenaline-evoked [Ca2+]i rises were not blocked by the intracellular perfusion of heparin, suggesting that these fluctuations are independent of the binding of InsP3 to its receptor.
摘要
在单个豚鼠肝细胞中研究了β-肾上腺素能受体激动剂异丙肾上腺素和环磷酸腺苷（cAMP）对胞质游离钙离子（[Ca2+]i）的影响。与去甲肾上腺素或血管紧张素II等依赖肌醇三磷酸（InsP3）的激动剂一样，异丙肾上腺素（0.5 - 10微摩尔）和cAMP（50 - 100毫摩尔，通过膜片吸管灌注到细胞中）能够产生[Ca2+]i的快速和缓慢波动。在无细胞外钙离子的情况下也观察到了对异丙肾上腺素和cAMP的反应。细胞内灌注肝素并未阻断异丙肾上腺素诱发的[Ca2+]i升高，这表明这些波动与InsP3与其受体的结合无关。
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