Bhaskar Pallooru Muni, Mathiselvam Manoharan, Loganathan Duraikkannu
Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.
Carbohydr Res. 2008 Jul 21;343(10-11):1801-7. doi: 10.1016/j.carres.2008.05.006. Epub 2008 May 8.
H-Beta zeolite, a microporous solid acid, is demonstrated to be an efficient catalyst for the selective deprotection of cyclic as well as acyclic O-isopropylidene sugar acetals derived from d-glucose, D-xylose, D-mannose, and D-mannitol in aqueous MeOH at room temperature. A notable observation is the conversion of d-mannitol triacetonide into 1,2:3,4-di-O-isopropylidene-D-mannitol (48%) and 3,4-O-isopropylidene-D-mannitol (36%) brought about in 6h by H-beta zeolite and the non-occurrence of any hydrolysis in the case of H-ZSM-5 catalyzed reaction in 24h under the same conditions.
H-β沸石是一种微孔固体酸，已证明它是一种高效催化剂，可在室温下于甲醇水溶液中对由d-葡萄糖、D-木糖、D-甘露糖和D-甘露醇衍生的环状及非环状O-异亚丙基糖缩醛进行选择性脱保护。一个值得注意的现象是，H-β沸石在6小时内可将甘露醇三丙酮化物转化为1,2:3,4-二-O-异亚丙基-D-甘露醇（48%）和3,4-O-异亚丙基-D-甘露醇（36%），而在相同条件下，H-ZSM-5催化反应24小时未发生任何水解。
