Kizu A, Yoshida Y, Miyagishi T
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
J Neural Transm Gen Sect. 1991;83(1-2):149-53. doi: 10.1007/BF01244461.
Repeated administrations of 7.5 mg/kg of pentazocine (for 14 days) resulted in a significant decrease in the affinity of 3H-haloperidol binding to rat cortical sigma receptors without any changes in the maximal number of binding sites (Bmax). On the other hand, similar treatment with haloperidol (2 or 4 mg/kg) induced a dose dependent decrease in the Bmax values without affecting the affinity of the 3H-haloperidol binding. These findings indicate that rat cortical sigma receptors are differentially regulated by pentazocine and haloperidol.
