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本文引用的文献

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Small-angle X-ray scattering of reduced ribonuclease A: effects of solution conditions and comparisons with a computational model of unfolded proteins.还原型核糖核酸酶A的小角X射线散射：溶液条件的影响以及与未折叠蛋白质计算模型的比较
J Mol Biol. 2008 Apr 11;377(5):1576-92. doi: 10.1016/j.jmb.2008.02.009. Epub 2008 Feb 14.
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A kinetic intermediate that regulates proper folding of a group II intron RNA.一种调节II类内含子RNA正确折叠的动力学中间体。
J Mol Biol. 2008 Jan 11;375(2):572-80. doi: 10.1016/j.jmb.2007.10.052. Epub 2007 Oct 24.
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Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures.转录过程中非编码RNA的折叠由暂停诱导的非天然结构促进。
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17995-8000. doi: 10.1073/pnas.0705038104. Epub 2007 Nov 6.
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Folding of a universal ribozyme: the ribonuclease P RNA.一种通用核酶的折叠：核糖核酸酶P RNA
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Branching in the sequential folding pathway of cytochrome c.细胞色素c连续折叠途径中的分支情况。
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The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain.作为超快速独立折叠结构域的螺旋-转角-螺旋基序：Engrailed 同源结构域的折叠途径。
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Thermodynamics and kinetics for base-pair opening in the P1 duplex of the Tetrahymena group I ribozyme.嗜热四膜虫I组核酶P1双链体碱基对打开的热力学与动力学
Nucleic Acids Res. 2007;35(9):2965-74. doi: 10.1093/nar/gkm184. Epub 2007 Apr 16.
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A unified mechanism for protein folding: predetermined pathways with optional errors.蛋白质折叠的统一机制：具有可选错误的预定途径。
Protein Sci. 2007 Mar;16(3):449-64. doi: 10.1110/ps.062655907.
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Fully reduced ribonuclease A does not expand at high denaturant concentration or temperature.完全还原的核糖核酸酶A在高变性剂浓度或温度下不会展开。
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10
Malleability of protein folding pathways: a simple reason for complex behaviour.蛋白质折叠途径的可塑性：复杂行为的一个简单原因。
Curr Opin Struct Biol. 2007 Feb;17(1):21-9. doi: 10.1016/j.sbi.2007.01.008. Epub 2007 Jan 23.

动力学障碍以及拓扑结构在蛋白质和RNA折叠中的作用。

Kinetic barriers and the role of topology in protein and RNA folding.

作者信息

Sosnick Tobin R

机构信息

University of Chicago, 929 East 57th Street, GCIS W107E, Chicago, IL 60637, USA.

出版信息

Protein Sci. 2008 Aug;17(8):1308-18. doi: 10.1110/ps.036319.108. Epub 2008 May 23.

DOI:10.1110/ps.036319.108
PMID:18502978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2492822/
Abstract

This review compares the folding behavior of proteins and RNAs. Topics covered include the role of topology in the determination of folding rates, major folding events including collapse, properties of denatured states, pathway heterogeneity, and the influence of the mode of initiation on the folding pathway.

摘要

本综述比较了蛋白质和RNA的折叠行为。涵盖的主题包括拓扑结构在折叠速率测定中的作用、主要折叠事件（包括折叠塌陷）、变性状态的性质、折叠途径的异质性以及起始方式对折叠途径的影响。