Pet191是酿酒酵母中的一种细胞色素c氧化酶组装因子。
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.
作者信息
Khalimonchuk Oleh, Rigby Kevin, Bestwick Megan, Pierrel Fabien, Cobine Paul A, Winge Dennis R
机构信息
University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
出版信息
Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.
Abstract
The twin-Cx(9)C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx(9)C motif class of proteins in being independent of the Mia40 pathway.
摘要
双Cx(9)C基序蛋白Pet191对细胞色素c氧化酶的成熟至关重要。该基序中的半胱氨酸残基在功能上很重要，并且似乎存在于与线粒体内膜相关的大型寡聚复合物中的二硫键中。Pet191的导入不同于其他双Cx(9)C基序类蛋白，它不依赖于Mia40途径。
相似文献
1
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.
Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.
2
Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae.
Curr Genet. 1993 Jan;23(1):9-14. doi: 10.1007/BF00336742.
3
Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae.
J Biol Chem. 2011 Jan 7;286(1):555-66. doi: 10.1074/jbc.M110.188805. Epub 2010 Nov 10.
4
Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system.
Mol Biol Cell. 2011 Oct;22(20):3758-67. doi: 10.1091/mbc.E11-04-0296. Epub 2011 Aug 24.
5
Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18.
Genetics. 2009 Jun;182(2):519-28. doi: 10.1534/genetics.109.101196. Epub 2009 Mar 23.
6
Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast.
Hum Mol Genet. 2011 Jun 15;20(12):2379-93. doi: 10.1093/hmg/ddr145. Epub 2011 Apr 5.
7
characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiae.
J Biol Chem. 2007 Apr 6;282(14):10233-42. doi: 10.1074/jbc.M610082200. Epub 2007 Jan 19.
8
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.
J Mol Biol. 2007 Jan 19;365(3):612-20. doi: 10.1016/j.jmb.2006.10.038. Epub 2006 Oct 14.
9
The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.
Mol Cell Biol. 2013 Oct;33(20):4128-37. doi: 10.1128/MCB.00747-13. Epub 2013 Aug 26.
10
Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria.
J Biol Chem. 2009 Jan 16;284(3):1353-63. doi: 10.1074/jbc.M805035200. Epub 2008 Nov 14.
引用本文的文献
1
COA5 has an essential role in the early stage of mitochondrial complex IV assembly.
Life Sci Alliance. 2025 Jan 8;8(3). doi: 10.26508/lsa.202403013. Print 2025 Mar.
2
More than Just Bread and Wine: Using Yeast to Understand Inherited Cytochrome Oxidase Deficiencies in Humans.
Int J Mol Sci. 2024 Mar 29;25(7):3814. doi: 10.3390/ijms25073814.
3
Coordination of metal center biogenesis in human cytochrome c oxidase.
Nat Commun. 2022 Jun 24;13(1):3615. doi: 10.1038/s41467-022-31413-1.
4
Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.
Front Cell Dev Biol. 2021 Sep 7;9:720656. doi: 10.3389/fcell.2021.720656. eCollection 2021.
5
Regulation of COX Assembly and Function by Twin CXC Proteins-Implications for Human Disease.
Cells. 2021 Jan 20;10(2):197. doi: 10.3390/cells10020197.
6
Building the Cu site of cytochrome oxidase: A complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins.
J Biol Chem. 2018 Mar 30;293(13):4644-4652. doi: 10.1074/jbc.R117.816132. Epub 2017 Sep 29.
7
Landscape of submitochondrial protein distribution.
Nat Commun. 2017 Aug 18;8(1):290. doi: 10.1038/s41467-017-00359-0.
8
Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk.
Biochim Biophys Acta. 2016 Nov;1863(11):2613-2623. doi: 10.1016/j.bbamcr.2016.07.004. Epub 2016 Jul 15.
9
Mitochondrial ClpP activity is required for cisplatin resistance in human cells.
Biochim Biophys Acta. 2016 Feb;1862(2):252-64. doi: 10.1016/j.bbadis.2015.12.005. Epub 2015 Dec 7.
10
Intermembrane space proteome of yeast mitochondria.
Mol Cell Proteomics. 2012 Dec;11(12):1840-52. doi: 10.1074/mcp.M112.021105. Epub 2012 Sep 15.
本文引用的文献
1
The disulfide relay system of mitochondria is connected to the respiratory chain.
J Cell Biol. 2007 Nov 5;179(3):389-95. doi: 10.1083/jcb.200707123. Epub 2007 Oct 29.
2
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
EMBO J. 2007 Oct 17;26(20):4335-46. doi: 10.1038/sj.emboj.7601861. Epub 2007 Sep 20.
3
Blue native PAGE.
Nat Protoc. 2006;1(1):418-28. doi: 10.1038/nprot.2006.62.
4
characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiae.
J Biol Chem. 2007 Apr 6;282(14):10233-42. doi: 10.1074/jbc.M610082200. Epub 2007 Jan 19.
5
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.
J Mol Biol. 2007 Jan 19;365(3):612-20. doi: 10.1016/j.jmb.2006.10.038. Epub 2006 Oct 14.
6
Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.
J Biol Chem. 2006 Dec 1;281(48):36552-9. doi: 10.1074/jbc.M606839200. Epub 2006 Sep 28.
7
Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.
Biochim Biophys Acta. 2006 Jul;1763(7):759-72. doi: 10.1016/j.bbamcr.2006.03.002. Epub 2006 Mar 31.
8
The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins.
J Mol Biol. 2005 Oct 28;353(3):485-92. doi: 10.1016/j.jmb.2005.08.051. Epub 2005 Sep 8.
9
A disulfide relay system in the intermembrane space of mitochondria that mediates protein import.
Cell. 2005 Jul 1;121(7):1059-69. doi: 10.1016/j.cell.2005.04.011.
10
Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding.
Structure. 2005 May;13(5):713-22. doi: 10.1016/j.str.2005.02.015.
Zotero 插件