Pet191是酿酒酵母中的一种细胞色素c氧化酶组装因子。
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.
作者信息
Khalimonchuk Oleh, Rigby Kevin, Bestwick Megan, Pierrel Fabien, Cobine Paul A, Winge Dennis R
机构信息
University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
出版信息
Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.
Abstract
The twin-Cx(9)C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx(9)C motif class of proteins in being independent of the Mia40 pathway.
摘要
双Cx(9)C基序蛋白Pet191对细胞色素c氧化酶的成熟至关重要。该基序中的半胱氨酸残基在功能上很重要，并且似乎存在于与线粒体内膜相关的大型寡聚复合物中的二硫键中。Pet191的导入不同于其他双Cx(9)C基序类蛋白，它不依赖于Mia40途径。
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