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Pet191是酿酒酵母中的一种细胞色素c氧化酶组装因子。

Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.

作者信息

Khalimonchuk Oleh, Rigby Kevin, Bestwick Megan, Pierrel Fabien, Cobine Paul A, Winge Dennis R

机构信息

University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.

出版信息

Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.

DOI:10.1128/EC.00132-08
PMID:18503002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2519776/
Abstract

The twin-Cx(9)C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx(9)C motif class of proteins in being independent of the Mia40 pathway.

摘要

双Cx(9)C基序蛋白Pet191对细胞色素c氧化酶的成熟至关重要。该基序中的半胱氨酸残基在功能上很重要，并且似乎存在于与线粒体内膜相关的大型寡聚复合物中的二硫键中。Pet191的导入不同于其他双Cx(9)C基序类蛋白，它不依赖于Mia40途径。

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本文引用的文献

1
The disulfide relay system of mitochondria is connected to the respiratory chain.线粒体的二硫键中继系统与呼吸链相连。
J Cell Biol. 2007 Nov 5;179(3):389-95. doi: 10.1083/jcb.200707123. Epub 2007 Oct 29.
2
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.Coa1将Mss51的翻译后功能与细胞色素c氧化酶组装过程中Cox1辅因子的插入联系起来。
EMBO J. 2007 Oct 17;26(20):4335-46. doi: 10.1038/sj.emboj.7601861. Epub 2007 Sep 20.
3
Blue native PAGE.蓝色非变性聚丙烯酰胺凝胶电泳
Nat Protoc. 2006;1(1):418-28. doi: 10.1038/nprot.2006.62.
4
characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiae.酿酒酵母细胞色素c氧化酶组装因子Cox19的特性分析
J Biol Chem. 2007 Apr 6;282(14):10233-42. doi: 10.1074/jbc.M610082200. Epub 2007 Jan 19.
5
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.作为线粒体导入途径（MIA）底物的新型线粒体内膜间隙蛋白
J Mol Biol. 2007 Jan 19;365(3):612-20. doi: 10.1016/j.jmb.2006.10.038. Epub 2006 Oct 14.
6
Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.用于细胞色素氧化酶和超氧化物歧化酶金属化的线粒体基质铜复合物。
J Biol Chem. 2006 Dec 1;281(48):36552-9. doi: 10.1074/jbc.M606839200. Epub 2006 Sep 28.
7
Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.铜向线粒体的转运及铜金属酶的组装。
Biochim Biophys Acta. 2006 Jul;1763(7):759-72. doi: 10.1016/j.bbamcr.2006.03.002. Epub 2006 Mar 31.
8
The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins.线粒体必需蛋白Erv1在膜间隙蛋白的生物合成过程中与Mia40协同作用。
J Mol Biol. 2005 Oct 28;353(3):485-92. doi: 10.1016/j.jmb.2005.08.051. Epub 2005 Sep 8.
9
A disulfide relay system in the intermembrane space of mitochondria that mediates protein import.线粒体膜间隙中一个介导蛋白质导入的二硫键中继系统。
Cell. 2005 Jul 1;121(7):1059-69. doi: 10.1016/j.cell.2005.04.011.
10
Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding.对Cox17的折叠研究揭示了半胱氨酸氧化与铜结合之间的重要相互作用。
Structure. 2005 May;13(5):713-22. doi: 10.1016/j.str.2005.02.015.