Antonova N, Zvetkova E, Ivanov I, Savov Y
Institute of Mechanics and Biomechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Clin Hemorheol Microcirc. 2008;39(1-4):53-61.
A group of 15 chronic opioid addicts (DA) with mean age 26.5+/-7.3 years was studied by means of a rotational Contraves Low Shear 30 viscometer and the results have been compared with a control group of 19 healthy subjects. It was found that the mean whole blood viscosity values of the investigated group of heroin abusers (n=15) were elevated compared to that of healthy persons (n=19) over the whole shear rate range and fell by more than ten orders of magnitude (Savov et al., 2006). The present investigation uses the coefficients of the models of Ostwald-de-Walle (power law) and Herschel-Bulkley law, which describe whole blood flow curves (tau-gamma) within the shear rates range from 10(-2) to 10(2) s(-1) and itself incorporate whole blood viscosity data in the entire shear rate range. A significant difference in the mean yield shear stress tau(0) values of the drug abusers' group compared to the controls was found. A strong positive linear correlation was determined between the parameters of RBC aggregation in the group of heroin addicts confirming our previous results (Ivanov and Antonova, 2005; Savov, Zvetkova et al., 2007; Savov, Antonova et al., 2007) for intensive RBC and platelet aggregation and morphological changes in DA group.
采用Contraves Low Shear 30旋转粘度计对15名平均年龄为26.5±7.3岁的慢性阿片类药物成瘾者（DA）进行了研究，并将结果与19名健康受试者组成的对照组进行了比较。结果发现，在所研究的海洛因滥用者组（n = 15）中，全血粘度平均值在整个剪切速率范围内均高于健康人组（n = 19），且下降幅度超过十个数量级（萨沃夫等人，2006年）。本研究使用了奥斯特瓦尔德 - 德瓦勒（幂律）模型和赫歇尔 - 布克利模型的系数，这些系数描述了剪切速率范围从10^(-2)到10^(2) s^(-1)内的全血流变曲线（τ - γ），并且本身包含了整个剪切速率范围内的全血粘度数据。研究发现，与对照组相比，药物滥用者组的平均屈服剪切应力τ(0)值存在显著差异。在海洛因成瘾者组中，红细胞聚集参数之间确定了强烈的正线性相关性，这证实了我们之前关于DA组红细胞和血小板强烈聚集以及形态变化的研究结果（伊万诺夫和安东诺娃，2005年；萨沃夫、兹韦特科娃等人，2007年；萨沃夫、安东诺娃等人，2007年）。
