Thielen A-M, Barde C, Marazza G, Saurat J-H
Dermatology Department, University Hospital of Geneva, Geneva, Switzerland.
Dermatology. 2008;217(2):137-9. doi: 10.1159/000134613. Epub 2008 May 26.
Hallopeau's acrodermatitis is characterized by the presence of aseptic pustules on an inflammatory basis of the periungual or subungual region. The cyclic recurrences induce important physical and psychological morbidity. By analogy to the efficacy of TNF-alpha antagonists in the treatment of generalized pustular psoriasis, our patient illustrates the long-term efficacy and safety of etanercept (Enbrel) in the treatment of Hallopeau's acrodermatitis refractory to infliximab (Remicade). This treatment alternative should in consequence be considered in patients with a recalcitrant form of a potentially debilitating disease.
哈洛佩奥肢端皮炎的特征是在甲周或甲下区域的炎症基础上出现无菌性脓疱。周期性复发会导致严重的身心疾病。鉴于肿瘤坏死因子-α拮抗剂在治疗泛发性脓疱型银屑病中的疗效，我们的患者证明了依那西普（恩利）在治疗对英夫利昔单抗（类克）耐药的哈洛佩奥肢端皮炎方面的长期疗效和安全性。因此，对于患有这种潜在致残性疾病的顽固形式的患者，应考虑这种治疗选择。
