Kumagai K, Tashiro E, Tashiro N, Moroe K, Hiroki T, Arakawa K
Department of Internal Medicine, Fukuoka University, School of Medicine, Japan.
Clin Cardiol. 1991 Jan;14(1):62-4. doi: 10.1002/clc.4960140113.
The effects of dibutyryl cyclic AMP (DBcAMP) on ventricular vulnerability during complete atrioventricular block (CAVB) were studied one week after transarterial electrical ablation of the AV junction in 18 closed-chest dogs. All dogs exhibited CAVB and a stable ventricular escape rhythm with a mean cycle length of 1812 +/- 638 ms. After the administration of DBcAMP at a rate of 0.1 mg/kg/min for 30 min, the ventricular cycle length was significantly shortened, and the QTc interval was slightly prolonged, although the QT interval did not change. The ventricular fibrillation threshold after the administration of DBcAMP was significantly increased (from 12.2 +/- 3 84 to 18.4 +/- 5.08 mA, p less than 0.01). Thus, it was demonstrated that DBcAMP exhibited suppressive effects on the ventricular vulnerability in the experimentally induced CAVB.
在18只开胸犬经动脉电消融房室结一周后，研究了二丁酰环磷腺苷（DBcAMP）对完全性房室传导阻滞（CAVB）期间心室易损性的影响。所有犬均表现为CAVB和稳定的心室逸搏心律，平均周期长度为1812±638毫秒。以0.1毫克/千克/分钟的速率输注DBcAMP 30分钟后，心室周期长度显著缩短，QTc间期略有延长，尽管QT间期未改变。输注DBcAMP后的心室颤动阈值显著升高（从12.2±3.84升高至18.4±5.08毫安，p<0.01）。因此，证明DBcAMP对实验诱导的CAVB中的心室易损性具有抑制作用。
