Anokhin Andrey P, Golosheykin Simon, Heath Andrew C
Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8134, St. Louis, MO 63108, USA.
Psychophysiology. 2008 Jul;45(4):524-34. doi: 10.1111/j.1469-8986.2008.00664.x. Epub 2008 May 20.
Monitoring the correspondence between the intended and actually executed action, a fundamental mechanism of behavioral regulation, is reflected by error-related negativity (ERN), an ERP component generated by the anterior cingulate cortex. This study examined genetic influences on the ERN and other components related to action monitoring (correct negativity, CRN, and error positivity, Pe). A flanker task was administered to adolescent twins (age 12) including 99 monozygotic (MZ) and 175 dizygotic (DZ) pairs. Genetic analysis showed substantial heritability of all three ERP components (40%-60%) and significant genetic correlations between them. This study provides the first evidence for heritable individual differences in the neural substrates of action monitoring and suggests that ERN, CRN, and Pe can potentially serve as endophenotypes for genetic studies of personality traits and psychopathology associated with abnormal regulation of behavior.
监测预期动作与实际执行动作之间的对应关系，这一行为调节的基本机制，由错误相关负波（ERN）反映出来，ERN是一种由前扣带回皮层产生的事件相关电位成分。本研究考察了基因对ERN以及其他与动作监测相关成分（正确负波，CRN，和错误正波，Pe）的影响。对12岁的青少年双胞胎进行了侧翼任务测试，包括99对同卵双胞胎（MZ）和175对异卵双胞胎（DZ）。基因分析表明，这三种事件相关电位成分均具有较高的遗传力（40%-60%），且它们之间存在显著的遗传相关性。本研究首次为动作监测神经基础中的遗传个体差异提供了证据，并表明ERN、CRN和Pe有可能作为与行为异常调节相关的人格特质和精神病理学基因研究的内表型。
