Gartel Andrei L
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Biochim Biophys Acta. 2008 Dec;1786(2):83-6. doi: 10.1016/j.bbcan.2008.04.004. Epub 2008 May 8.
Transcriptional inhibitors (TI) repress global transcription and induce apoptosis. It has been suggested that induction of p53 is one of the hallmarks of global transcriptional repression. Two recent papers suggested that treatment of human cancer cells with TIs, leads to p53-dependent, transcription-independent or p53-dependent, transcription-dependent apoptosis. The latter mechanism is linked to the fact that TIs can be selective in their inhibitory effects thereby permitting transcription of some genes. However, the majority of other published data suggest that these drugs induce p53-independent apoptosis. In this article I discuss the mechanisms of TI-dependent cell death and the potential role of p53 in this process.
转录抑制剂（TI）可抑制整体转录并诱导细胞凋亡。有人提出，p53的诱导是整体转录抑制的标志之一。最近的两篇论文表明，用TI处理人类癌细胞会导致p53依赖性、转录非依赖性或p53依赖性、转录依赖性细胞凋亡。后一种机制与TI在其抑制作用中具有选择性这一事实有关，从而允许某些基因的转录。然而，其他大多数已发表的数据表明，这些药物会诱导p53非依赖性细胞凋亡。在本文中，我将讨论TI依赖性细胞死亡的机制以及p53在此过程中的潜在作用。
