Perkins Jonathan A, Maniglia Claudia, Magit Anthony, Sidhu Manrita, Manning Scott C, Chen Eunice Y
Division of Pediatric Otolaryngology, Children's Hospital and Regional Medical Center, Seattle, WA 98105-0371, USA.
Otolaryngol Head Neck Surg. 2008 Jun;138(6):772-7. doi: 10.1016/j.otohns.2008.02.016.
Evaluate clinical and radiographic characteristics of spontaneously regressing lymphatic malformations ("lesions").
Retrospective review of 104 consecutive patients with cervicofacial lesions, with 1-year follow-up.
patient's age; lesion stage, location, radiographic characteristics; treatment. Data analysis using descriptive and Fischer exact tests.
Spontaneously regressing lesions were identified in 13 of 104 (12.5%) patients. Five of 13 had in utero lesions, which persisted at birth; presenting age in the remaining eight patients was 2 to 138 months. Lesions regressed within 2 to 7 months. Lesion stage: I (7 of 13), II (2 of 13), III (4 of 13). Lesion location: left neck (9 of 13), right neck (4 of 13), posterior neck (10 of 13). All 13 resolving lesions were macrocystic with fewer than five septations in 11 of 13. Comparison of a resolving lesion cohort with a nonresolving lesion cohort demonstrated that disappearing lesions are more likely to have fewer than five septae and to be macrocystic (P < 0.05). Treatment was none in seven of 13, antibiotics in four of 13, and redundant skin excision in two of 13.
Spontaneous lesion regression can occur, and these lesions have distinct features. Lesions with these characteristics can be observed.
评估自然消退型淋巴管畸形（“病变”）的临床和影像学特征。
对104例连续的头颈部病变患者进行回顾性研究，并随访1年。
患者年龄；病变分期、位置、影像学特征；治疗情况。采用描述性统计和费舍尔精确检验进行数据分析。
104例患者中有13例（12.5%）病变自然消退。13例中有5例在子宫内即有病变，出生后持续存在；其余8例患者的发病年龄为2至138个月。病变在2至7个月内消退。病变分期：I期（13例中的7例），II期（13例中的2例），III期（13例中的4例）。病变位置：左侧颈部（13例中的9例），右侧颈部（13例中的4例），后颈部（13例中的10例）。13例消退的病变均为大囊型，13例中有11例分隔少于5个。将消退病变组与未消退病变组进行比较，发现消退的病变更可能分隔少于5个且为大囊型（P<0.05）。13例中有7例未接受治疗，13例中有4例使用抗生素治疗，13例中有2例进行了多余皮肤切除术。
病变可自然消退，且这些病变具有独特特征。具有这些特征的病变可进行观察。
