多囊卵巢综合征年轻女性胰岛素抵抗的评估。
Assessment of insulin resistance in young women with polycystic ovary syndrome.
作者信息
Jensterle Mojca, Weber Matthias, Pfeifer Marija, Prezelj Janez, Pfutzner Andreas, Janez Andrej
机构信息
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia.
出版信息
Int J Gynaecol Obstet. 2008 Aug;102(2):137-40. doi: 10.1016/j.ijgo.2008.03.017. Epub 2008 May 27.
OBJECTIVES
To determine whether serum levels of potential markers could detect insulin resistance (IR) in young women with polycystic ovary syndrome (PCOS).
METHODS
Serum levels of fasting glucose, insulin, intact proinsulin, resistin, and adiponectin were measured in 50 women with PCOS and known homeostatic model assessment (HOMA)-IR values (>or=2 indicating IR). The women were all younger than 25 years.
RESULTS
Of the 50 women, 49 had undetectable levels of resistin, 50 had intact proinsulin levels within the normal range, and 50 had adiponectin levels of 8.4+/-3.3 mg/L, just below the normal range. When groups were compared, however, the 26 women (52%) with IR (HOMA-IR values >or=2) had significantly higher intact proinsulin levels (3.2+/-2.0 pmol/L vs 1.8+/-1.0 pmol/L; P<0.005) and significantly lower adiponectin levels (7.2+/-2.9 mg/L vs 9.7+/-3.3 mg/L; P<0.01), than the 24 women (48%) without IR.
CONCLUSION
Serum levels of intact proinsulin, resistin, or adiponectin were not detectors of IR in individual young women with PCOS.
目的
确定血清中潜在标志物水平能否检测多囊卵巢综合征（PCOS）年轻女性的胰岛素抵抗（IR）。
方法
检测了50名患有PCOS且已知稳态模型评估（HOMA）-IR值（≥2表明存在IR）的女性的空腹血糖、胰岛素、完整胰岛素原、抵抗素和脂联素的血清水平。这些女性均年龄小于25岁。
结果
50名女性中，49名抵抗素水平检测不到，50名完整胰岛素原水平在正常范围内，50名脂联素水平为8.4±3.3mg/L，略低于正常范围。然而，当进行组间比较时，26名（52%）存在IR（HOMA-IR值≥2）的女性的完整胰岛素原水平显著更高（3.2±2.0pmol/L对1.8±1.0pmol/L；P<0.005），脂联素水平显著更低（7.2±2.9mg/L对9.7±3.3mg/L；P<0.01），高于24名（48%）不存在IR的女性。
结论
血清中完整胰岛素原、抵抗素或脂联素水平并非PCOS年轻女性个体IR的检测指标。
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