Ramankulov Azizbek, Lein Michael, Johannsen Manfred, Schrader Mark, Miller Kurt, Loening Stefan A, Jung Klaus
Department of Urology, Charité - University Medicine Berlin, Campus Charité Mitte, Schumannstr. 20/21, 10117 Berlin, Germany.
Cancer Lett. 2008 Sep 28;269(1):85-92. doi: 10.1016/j.canlet.2008.04.022. Epub 2008 May 27.
The aim of the present study was to evaluate the clinical significance of the concentration of serum amyloid A (SAA) in patients with renal cell carcinoma (RCC). SAA protein was determined with enzyme-linked immunosorbent assay in serum samples of 55 healthy controls and 98 RCC patients subdivided into groups with localized tumor (N0M0, n=40), with lymph node metastases (N1M0, n=13), and distant metastases (M1, n=45). SAA concentrations in controls and N0M0 group of RCC were not different while SAA concentrations were significantly elevated in M1 patients compared to the N1M0 and N0M0 patients. In this respect, SAA provided an accurate detection of distant metastases with the area under the ROC curve of 0.86. SAA was identified as a significant independent factor of survival in RCC patients using the multivariate Cox proportional hazards regression model. SAA could be a useful analyte in predicting the survival outcome of RCC patients.
本研究的目的是评估血清淀粉样蛋白A（SAA）浓度在肾细胞癌（RCC）患者中的临床意义。采用酶联免疫吸附测定法测定了55名健康对照者和98名RCC患者血清样本中的SAA蛋白，这些RCC患者被分为局部肿瘤组（N0M0，n = 40）、有淋巴结转移组（N1M0，n = 13）和远处转移组（M1，n = 45）。对照组和RCC的N0M0组的SAA浓度无差异，而与N1M0和N0M0患者相比，M1患者的SAA浓度显著升高。在这方面，SAA对远处转移的检测准确率较高，ROC曲线下面积为0.86。使用多变量Cox比例风险回归模型，SAA被确定为RCC患者生存的一个显著独立因素。SAA可能是预测RCC患者生存结果的一种有用分析物。
