Yang Fang, Ma Ying, He Yuan-li
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 May;28(5):816-9.
To investigate the expression of vascular endothelial growth factor (VEGF) in eutopic and ectopic endometrium of in nude mice models of endometriosis and understand the role of VEGF in the development of endometriosis.
Nude mouse models of endometriosis were established by subcutaneous implantation and abdominal injection of human endometrium xenograft from patients with endometriosis. The morphology of the foci was observed microscopically, and VEGF expression was measured with immunohistochemistry.
Models of endometriosis were successfully established in 8 of the 10 mice receiving subcutaneous xenograft implantation and in 7 of the 10 mice with abdominal graft injection. Increased VEGF expression was observed in the ectopic endometrium in these models.
VEGF expression is increased in the ectopic endometrium of the nude mouse models, and this animal model may facilitate future studies of angiogenesis and antiangiogenesis therapy.
研究血管内皮生长因子（VEGF）在子宫内膜异位症裸鼠模型的在位及异位内膜中的表达，了解VEGF在子宫内膜异位症发生发展中的作用。
通过皮下植入和腹腔注射来自子宫内膜异位症患者的人子宫内膜异种移植物建立子宫内膜异位症裸鼠模型。显微镜下观察病灶形态，采用免疫组化法检测VEGF表达。
10只接受皮下异种移植物植入的小鼠中有8只成功建立子宫内膜异位症模型，10只接受腹腔移植物注射的小鼠中有7只成功建立模型。在这些模型的异位内膜中观察到VEGF表达增加。
裸鼠模型的异位内膜中VEGF表达增加，该动物模型可能有助于未来血管生成及抗血管生成治疗的研究。
