Aragona C, Bohnet H G, Friesen H G
Endocrinology. 1976 Oct;99(4):1017-22. doi: 10.1210/endo-99-4-1017.
Specific binding sites for prolactin (PRL) have been detected in membrane preparations from the liver of the male rat following castration. The magnitude of the increased binding following castration varied with the age of the animals and with the time after castration. The effect of castration did not appear to be PRL mediated, since increases or decreases of serum PRL levels after pharmacological agents had no effect on PRL binding. The pituitary, however, seems to have a critical role in mediating the increase in PRL binding. Adrenalectomy did not influence the extent of binding of PRL after castration. Testosterone administration, however, completely prevented the increased PRL binding which followed castration. These studies suggest that testosterone has a modulating effect on hepatic PRL binding sites. The maintenance of such binding activity requires not only PRL, but also a functioning pituitary.
在雄性大鼠阉割后的肝脏膜制剂中已检测到催乳素（PRL）的特异性结合位点。阉割后结合增加的幅度随动物年龄和阉割后的时间而变化。阉割的作用似乎不是由PRL介导的，因为药物处理后血清PRL水平的升高或降低对PRL结合没有影响。然而，垂体似乎在介导PRL结合增加方面起关键作用。肾上腺切除术不影响阉割后PRL的结合程度。然而，给予睾酮可完全阻止阉割后PRL结合的增加。这些研究表明，睾酮对肝脏PRL结合位点具有调节作用。维持这种结合活性不仅需要PRL，还需要一个功能正常的垂体。
