Chuang Yao-Chi, Thomas Catherine A, Tyagi Shachi, Yoshimura Naoki, Tyagi Pradeep, Chancellor Michael B
Department of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niao-Song Hsiang, Kaohsiung Hsien, Taiwan.
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Oct;19(10):1353-7. doi: 10.1007/s00192-008-0650-7. Epub 2008 May 27.
The objective of the study was to evaluate the local effects of three antimuscarinics excreted into human urine after oral ingestion. Two normal adult collected their voided urine after taking oral doses of tolterodine, darifenacin, and solifenacin for 7 days with a 14-day washout period. The urodynamic effect of intravesically administered human urine on carbachol-induced bladder overactivity was studied in female rats. Cystometric parameters were measured during continuous infusion of saline and human urine and then a mixture of carbachol (30 microM) and human urine. Carbachol significantly reduced the intercontraction interval and bladder capacity in the control (urine taken in the absence of oral antimuscarinics) and tolterodine- or darifenacin-administered groups. However, human urine obtained after taking solifenacin prevented the carbachol-induced detrusor overactivity. Urine excreted after oral ingestion of solifenacin provides a localized pharmacological advantage for the treatment of the overactive bladder syndrome.
本研究的目的是评估口服摄入后排泄到人体尿液中的三种抗毒蕈碱药物的局部作用。两名正常成年人在口服托特罗定、达非那新和索利那新7天，并经过14天的洗脱期后，收集其排尿。在雌性大鼠中研究了膀胱内注入人尿对卡巴胆碱诱导的膀胱过度活动的尿动力学作用。在持续输注生理盐水和人尿，然后是卡巴胆碱（30微摩尔）与人尿的混合物期间，测量膀胱测压参数。在对照组（未服用口服抗毒蕈碱药物时采集的尿液）以及服用托特罗定或达非那新的组中，卡巴胆碱显著缩短了收缩间期并降低了膀胱容量。然而，服用索利那新后获得的人尿可预防卡巴胆碱诱导的逼尿肌过度活动。口服索利那新后排泄的尿液为治疗膀胱过度活动症提供了局部药理学优势。
