Tyagi Pradeep, Tyagi Vikas, Yoshimura Naoki, Chancellor Michael
Departments of Urology, William Beaumont Hospital, MI, USA.
Indian J Urol. 2010 Jan-Mar;26(1):26-35. doi: 10.4103/0970-1591.60440.
Cannabinoids, the active components of Cannabis sativa (maijuana), and their derivatives produce a wide spectrum of central and peripheral effects, some of which may have clinical applications. The discovery of specific cannabinoid receptors and a family of endogenous ligands of those receptors has attracted much attention to the general cannabinoid pharmacology. In recent years, studies on the functional role of cannabinoid receptors in bladder have been motivated by the therapeutic effects of cannabinoids on voiding dysfunction in multiple sclerosis patients. In this review, we shall summarize the literature on the expression of cannabinoid receptors in urinary bladder and the peripheral influence of locally and systemically administered cannabinoids in the bladder. The ongoing search for cannabinoid-based therapeutic strategies devoid of psychotropic effects can be complemented with local delivery into bladder by the intravesical route. A greater understanding of the role of the peripheral CB(1) and CB(2) receptor system in lower urinary tract is necessary to allow the development of new treatment for pelvic disorders.
大麻素是大麻（ marijuana）的活性成分，其衍生物可产生广泛的中枢和外周效应，其中一些可能具有临床应用价值。特定大麻素受体以及这些受体的内源性配体家族的发现，引起了人们对大麻素药理学的广泛关注。近年来，大麻素对多发性硬化症患者排尿功能障碍的治疗作用激发了对大麻素受体在膀胱中功能作用的研究。在这篇综述中，我们将总结关于膀胱中大麻素受体表达以及局部和全身给予大麻素对膀胱外周影响的文献。正在进行的寻找无精神活性作用的基于大麻素的治疗策略，可以通过膀胱内途径局部给药来补充。深入了解外周CB(1)和CB(2)受体系统在下尿路中的作用，对于开发盆腔疾病的新治疗方法是必要的。
