Mielgo Antonia, Palomo Claudio
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo, 1072. 20080 San Sebastián, Spain.
Chem Asian J. 2008 Jun 2;3(6):922-48. doi: 10.1002/asia.200700417.
Alpha,alpha-diaryl(dialkyl)prolinol ethers constitute a potent organocatalyst family which has been shown to be very general for a broad range of reactions involving enamine and iminium ion activation or a combination of both. The reactions are characterized by an efficient steric control approach and can lead to a variety of alpha-, beta-, gamma-, and alpha,beta-functionalized carbonyl compounds with excellent stereocontrol. As a full expression of their catalytic activity, these compounds are also excellent promoters of elegant cascade processes and valuable catalysts in water-compatible systems.
α,α-二芳基（二烷基）脯氨醇醚构成了一类高效的有机催化剂家族，已被证明对涉及烯胺和亚胺离子活化或两者结合的广泛反应具有很强的通用性。这些反应的特点是采用了有效的空间控制方法，能够以优异的立体控制得到各种α-、β-、γ-以及α,β-官能化的羰基化合物。作为其催化活性的充分体现，这些化合物也是优雅的串联反应的优秀促进剂以及水相兼容体系中有价值的催化剂。
