Eida Sato, Ohki Masafumi, Sumi Misa, Yamada Toshiro, Nakamura Takashi
Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan.
J Magn Reson Imaging. 2008 Jun;27(6):1256-62. doi: 10.1002/jmri.21349.
To establish an MR factor analysis technique for two-dimensional (2D) MR dynamic structures of benign and malignant salivary gland tumors.
Dynamic contrast-enhanced MRI using a surface coil was performed on 36 patients with benign (N = 24) or malignant (N = 12) salivary gland tumors. Signal intensity kinetics in each pixel of the tumors after contrast medium injections were semiautomatically categorized into four patterns (slow uptake, rapid uptake with high washout, rapid uptake with low washout, and flat). The 2D distributions of the kinetic patterns in the tumors were compared with the histological features of the corresponding parts of the excised tumors and with overall kinetics obtained by a conventional analysis.
The MR factor analysis technique allowed the pixel-to-pixel evaluation of the contrast enhancement kinetics of the salivary gland tumors. The 2D distributions of the time-intensity curve (TIC) patterns correlated well with the histological features of the salivary gland tumors and allowed more detailed dynamic structures of the tumors compared with the results obtained by the conventional dynamic study analysis.
The proposed MR factor analysis would be clinically feasible to diagnose salivary gland tumors and tumor-like lesions.
建立一种针对涎腺良恶性肿瘤二维（2D）磁共振动态结构的磁共振因子分析技术。
对36例涎腺肿瘤患者（其中良性24例，恶性12例）使用表面线圈进行动态对比增强磁共振成像。在注射造影剂后，将肿瘤每个像素的信号强度动力学半自动分类为四种模式（缓慢摄取、快速摄取且高廓清、快速摄取且低廓清和平坦）。将肿瘤中动力学模式的二维分布与切除肿瘤相应部位的组织学特征以及通过传统分析获得的整体动力学进行比较。
磁共振因子分析技术能够对涎腺肿瘤的对比增强动力学进行逐像素评估。时间 - 强度曲线（TIC）模式的二维分布与涎腺肿瘤的组织学特征密切相关，与传统动态研究分析结果相比，能更详细地显示肿瘤的动态结构。
所提出的磁共振因子分析在临床上诊断涎腺肿瘤及肿瘤样病变是可行的。
