动态对比增强磁共振成像评估食管癌患者的肿瘤微循环：初步经验
Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: initial experience.
作者信息
Oberholzer Katja, Pohlmann Andreas, Schreiber Wolfgang, Mildenberger Peter, Kunz Peter, Schmidberger Heinz, Junginger Theodor, Düber Cristoph
机构信息
Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University Mainz, Mainz, Germany.
出版信息
J Magn Reson Imaging. 2008 Jun;27(6):1296-301. doi: 10.1002/jmri.21305.
PURPOSE
To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer.
MATERIALS AND METHODS
A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma.
RESULTS
Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k(21), P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate (P = 0.005), while amplitude A increased moderately after therapy (P = 0.136).
CONCLUSION
DCE-MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring.
目的
探讨动态对比增强磁共振成像（DCE-MRI）在食管癌患者肿瘤特征描述及放化疗（RCT）反应评估中的可行性及影响。
材料与方法
共48例患者接受DCE-MRI检查，基于双室模型函数评估肿瘤微循环。对12例鳞状细胞癌患者研究了RCT对动力学参数的影响。
结果
肿瘤微循环在组织学亚型方面存在差异：与腺癌相比，鳞状细胞癌的幅度A值（渗漏空间，P = 0.015）较低，造影剂交换率较高（k(21)，P = 0.225）。RCT导致造影剂交换率显著降低（P = 0.005），而治疗后幅度A适度增加（P = 0.136）。
结论
DCE-MRI在食管癌患者中可行，可揭示治疗效果，因此可能有助于治疗管理和监测。
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