Oberholzer Katja, Pohlmann Andreas, Schreiber Wolfgang, Mildenberger Peter, Kunz Peter, Schmidberger Heinz, Junginger Theodor, Düber Cristoph
Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University Mainz, Mainz, Germany.
J Magn Reson Imaging. 2008 Jun;27(6):1296-301. doi: 10.1002/jmri.21305.
To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer.
A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma.
Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k(21), P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate (P = 0.005), while amplitude A increased moderately after therapy (P = 0.136).
DCE-MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring.
探讨动态对比增强磁共振成像（DCE-MRI）在食管癌患者肿瘤特征描述及放化疗（RCT）反应评估中的可行性及影响。
共48例患者接受DCE-MRI检查，基于双室模型函数评估肿瘤微循环。对12例鳞状细胞癌患者研究了RCT对动力学参数的影响。
肿瘤微循环在组织学亚型方面存在差异：与腺癌相比，鳞状细胞癌的幅度A值（渗漏空间，P = 0.015）较低，造影剂交换率较高（k(21)，P = 0.225）。RCT导致造影剂交换率显著降低（P = 0.005），而治疗后幅度A适度增加（P = 0.136）。
DCE-MRI在食管癌患者中可行，可揭示治疗效果，因此可能有助于治疗管理和监测。
