Alonci A, Allegra A, Bellomo G, Penna G, D'Angelo A, Quartarone E, Musolino C
Division of Haematology, University of Messina, Messina, Italy.
Hematol Oncol. 2008 Dec;26(4):235-9. doi: 10.1002/hon.865.
Authors evaluated some markers of angiogenetic activity in patients with chronic myeloproliferative diseases (CMDs). In this study by using a cytofluorimetric analysis we evaluated circulating endothelial progenitor cells (EPCs) in patients with chronic myeloproliferative disease. Moreover, in the same group of subjects, we evaluated serum levels of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR2). In our patients, we have found an increase in the number of endothelial progenitor cells in primary myelofibrosis (PMF) and polycythaemia vera (PV) patients, while an increase of circulating endothelial cells (CECs) was found in all patients with CMD. Moreover, we found higher serum levels of VEGF with respect to control subjects in every group of patients with CMD, and a not significant reduction of VEGFR2 levels in essential thrombocythaemia (ET) patients. A correlation was also found in PV patients between VEGF levels and erythrocyte number and in PMF subjects with the count of white cells. Our data suggest that some markers of angiogenesis are activated in CMD patients and angiogenesis may have a role in the pathophysiology of chronic myeloproliferative disorders.
作者评估了慢性骨髓增殖性疾病（CMDs）患者血管生成活性的一些标志物。在本研究中，我们通过细胞荧光分析评估了慢性骨髓增殖性疾病患者循环内皮祖细胞（EPCs）。此外，在同一组受试者中，我们评估了血清血管内皮生长因子（VEGF）和血管内皮生长因子受体-2（VEGFR2）水平。在我们的患者中，我们发现原发性骨髓纤维化（PMF）和真性红细胞增多症（PV）患者的内皮祖细胞数量增加，而所有CMDs患者的循环内皮细胞（CECs）均增加。此外，我们发现每一组CMDs患者的血清VEGF水平均高于对照受试者，而原发性血小板增多症（ET）患者的VEGFR2水平有不显著降低。在PV患者中还发现VEGF水平与红细胞数量之间存在相关性，在PMF患者中与白细胞计数存在相关性。我们的数据表明，CMDs患者的一些血管生成标志物被激活，血管生成可能在慢性骨髓增殖性疾病的病理生理学中起作用。
