Boehm Daniel Ulrich, Lebrecht Antje, Maltaris Theodoros, Schmidt Marcus, Siggelkow Wulf, Fischer Susanne, Kandelhart Eva, Koelbl Heinz
Department of Obstetrics and Gynecology, Johannes Gutenberg University Mainz, Mainz, Germany.
Anticancer Res. 2008 Mar-Apr;28(2B):1207-11.
The goals of breast-conserving surgery are to provide the survival equivalent of mastectomy, a cosmetically acceptable breast and a low rate of locoregional recurrence in the treated breast. This retrospective study investigated the impact of the resection volume on locoregional recurrence after breast-conserving therapy in patients with early-stage invasive breast cancer.
Retrospective data from 185 women who were treated for operable breast tumours by breast-conserving surgery between 1995-1999 at the Martin-Luther-University in Halle/Germany were included in our study. Extent of total resection volume (TRV), tumour volume (V) and difference volume (DV) was compared for the influence on locoregional recurrence.
Our data showed no significant correlation between the risk of locoregional recurrence and the extent of resection volume. Predictors of an increased risk of locoregional recurrence after breast-conserving surgery were large primary tumour, grading, lymphatic vascular invasion, hormone receptor status and lack of radiotherapy or hormonal therapy.
According to the accuracy of locoregional disease control and maintenance of the breast's shape, our results support conservative surgery in early-stage breast cancer followed by radiotherapy and adjuvant systemic therapy.
保乳手术的目标是提供与乳房切除术相当的生存率、外观可接受的乳房以及治疗乳房的局部区域复发率低。这项回顾性研究调查了切除体积对早期浸润性乳腺癌患者保乳治疗后局部区域复发的影响。
我们的研究纳入了1995年至1999年在德国哈雷马丁路德大学接受保乳手术治疗可手术乳腺肿瘤的185名女性的回顾性数据。比较了总切除体积（TRV）、肿瘤体积（V）和差异体积（DV）对局部区域复发的影响。
我们的数据显示局部区域复发风险与切除体积范围之间无显著相关性。保乳手术后局部区域复发风险增加的预测因素包括原发肿瘤大、分级、淋巴管浸润、激素受体状态以及缺乏放疗或激素治疗。
根据局部区域疾病控制的准确性和乳房形状的维持，我们的结果支持早期乳腺癌采用保守手术，随后进行放疗和辅助全身治疗。
