Quintana Francisco J, Farez Mauricio F, Weiner Howard L
Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA.
J Cell Mol Med. 2008 Aug;12(4):1087-93. doi: 10.1111/j.1582-4934.2008.00375.x. Epub 2008 May 26.
Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. In this review we analyze the contribution of genomics, trancriptomics and proteomics in delineating these factors, as well as their utility for the monitoring of disease progression, the identification of new targets for therapeutic intervention and the early detection of individuals at risk.
多发性硬化症（MS）是一种由针对中枢神经系统（CNS）的自身免疫攻击引起的进行性神经疾病。MS被认为是遗传因素和环境因素之间复杂相互作用的结果。在本综述中，我们分析了基因组学、转录组学和蛋白质组学在阐明这些因素方面的作用，以及它们在监测疾病进展、确定治疗干预新靶点和早期发现高危个体方面的效用。
