Han Guan-Zhu, Liu Xi-Ping, Li Si-Shen
National Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an 271018, China.
Virol J. 2008 May 27;5:65. doi: 10.1186/1743-422X-5-65.
Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial. To determine the extent of homologous recombination in influenza B viruses, recombination analyses of 2,650 sequences representing all eight segments of the influenza B viruses were carried out. Only four sequences were indentified as putative recombinants, which were verified using phylogenetic methods. However, the mosaics detected here were much likely to represent cases of laboratory-generated artificial recombinants. As in other myxoviruses, it is unlikely that homologous recombination plays a major role in influenza B virus evolution.
乙型流感病毒会导致大量发病和死亡情况。流感病毒中同源重组的发生存在争议。为了确定乙型流感病毒中同源重组的程度，对代表乙型流感病毒所有八个基因片段的2650个序列进行了重组分析。仅鉴定出四个序列为推定重组体，并使用系统发育方法进行了验证。然而，此处检测到的嵌合体很可能代表实验室产生的人工重组体情况。与其他黏液病毒一样，同源重组在乙型流感病毒进化中不太可能起主要作用。
