Kaliks Rafael A, Del Giglio Auro
Hematology and Oncology Center for Studies and Research ABC School of Medicine, SP.
Rev Assoc Med Bras (1992). 2008 Mar-Apr;54(2):178-82. doi: 10.1590/s0104-42302008000200025.
Geriatricians and general practitioners often follow patients with metastatic prostate cancer. The epidemiology and basic treatment principles of metastatic prostate cancer are discussed aiming to update the topic for the non-oncologist. Hormone manipulation remains the basis of treatment, usually up to a second line of therapy. Selected cases are treated successfully with intermittent androgen ablation. When new hormone-independent clones arise, chemotherapy should be added to therapy that confers improved survival as well as better quality of life when based on taxanes. In specific situations, additional measures such as bisphosphonates and radiation therapy should be included in the treatment. As a rule, the public health system makes available the necessary medication to ensure treatment for the vast majority of patients in Brazil.
老年病医生和全科医生经常随访转移性前列腺癌患者。本文讨论了转移性前列腺癌的流行病学和基本治疗原则，旨在为非肿瘤学医生更新该主题。激素治疗仍然是治疗的基础，通常可持续到二线治疗。部分病例通过间歇性雄激素剥夺治疗获得成功。当出现新的激素非依赖性克隆时，应在基于紫杉烷类药物的治疗中加入化疗，这可提高生存率并改善生活质量。在特定情况下，治疗应包括双膦酸盐和放射治疗等额外措施。通常，巴西的公共卫生系统会提供必要的药物，以确保绝大多数患者能够得到治疗。
