Schultz R, Herz A
Eur J Pharmacol. 1976 Oct;39(2):429-32. doi: 10.1016/0014-2999(76)90157-6.
The endogenous ligands of opiate receptors, methionine-eukephalin and leucine-enkephalin, were tested for their ability to maintain or to reinduce dependence in myenteric plexus-longitudinal muscle strips taken from tolerant/dependent guinea pigs. Both peptides fully substituted for the function morphine exerts in this preparation. It is concluded that the enkephalins posses a high degree of dependence liability.
对阿片受体的内源性配体——甲硫氨酸脑啡肽和亮氨酸脑啡肽，检测了它们在取自耐受/依赖豚鼠的肠肌丛-纵行肌条中维持或再次诱导依赖性的能力。两种肽完全替代了吗啡在此制剂中发挥的功能。得出的结论是，脑啡肽具有高度的致依赖性倾向。
