Nefedov V B, Popova L A, Shergina E A
Probl Tuberk Bolezn Legk. 2008(4):24-8.
Vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/VC%, PEF, MEF25, MEF50, MEF75, TLC, TGV, residual volume (RV), R(aw), R(in), R(ex), DLCO-SB, DLCO-SS, PaO2, and PaCO2 were determined in 62 patients with chronic fibrocavernous tuberculosis. Lung dysfunctions were detected in 96.8% of the patients. Changes in lung volumes and capacities were found in 90.3%, impaired bronchial patency was in 90.3%, and pulmonary gas exchange dysfunction was in 79.0%. The lung volume and capacity changes appeared as decreased VC and FVC, decreased and increased TLC, TGV, RV; impaired bronchial patency presented as decreased PEF, MEF25, MEF50, MEF75, and FEV1/VC%; and increased R(aw), R(in), R(ex); pulmonary gas exchange dysfunction manifested itself as reduced DLCO-SB, DLCO-SS, PaO2, and decreased and increased PaCO2. The magnitude of the observed functional changes ranges from slight to significant and drastic with a predominance of considerable and drastic changes in lung volumes and capacities and mild impairments of bronchial patency and pulmonary gas exchange function.
对62例慢性纤维空洞型肺结核患者测定了肺活量(VC)、用力肺活量(FVC)、第1秒用力呼气量(FEV1)、FEV1/VC%、呼气峰流速(PEF)、25%最大呼气流量(MEF25)、50%最大呼气流量(MEF50)、75%最大呼气流量(MEF75)、肺总量(TLC)、胸廓气体容积(TGV)、残气量(RV)、气道阻力(R(aw))、吸气阻力(R(in))、呼气阻力(R(ex))、单次呼吸一氧化碳弥散量(DLCO-SB)、稳态一氧化碳弥散量(DLCO-SS)、动脉血氧分压(PaO2)和动脉血二氧化碳分压(PaCO2)。96.8%的患者存在肺功能障碍。90.3%的患者出现肺容积和容量变化,90.3%的患者存在支气管通畅性受损,79.0%的患者存在肺气体交换功能障碍。肺容积和容量变化表现为VC和FVC降低,TLC、TGV、RV降低或升高;支气管通畅性受损表现为PEF、MEF25、MEF50、MEF75降低以及FEV1/VC%降低;R(aw)、R(in)、R(ex)升高;肺气体交换功能障碍表现为DLCO-SB、DLCO-SS、PaO2降低,PaCO2降低或升高。观察到的功能变化程度从轻微到显著和剧烈不等,其中肺容积和容量的显著和剧烈变化以及支气管通畅性和肺气体交换功能的轻度受损占主导。