组蛋白H3赖氨酸4（H3K4）甲基化的分子机制及生理作用
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
作者信息
Shilatifard Ali
机构信息
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
出版信息
Curr Opin Cell Biol. 2008 Jun;20(3):341-8. doi: 10.1016/j.ceb.2008.03.019. Epub 2008 May 26.
Abstract
Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.
摘要
染色体表面装饰有多种组蛋白的翻译后修饰，这些修饰是许多以DNA为模板的过程调控所必需的。此类组蛋白修饰包括乙酰化、SUMO化、磷酸化、泛素化和甲基化。组蛋白修饰可以通过破坏染色体接触或通过调节非组蛋白与染色质的相互作用来发挥作用。在本综述中，将讨论关于酵母COMPASS和哺乳动物COMPASS样复合物对一种此类组蛋白修饰——组蛋白H3赖氨酸4（H3K4）甲基化的调控及其生理意义的最新研究结果。
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1
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Cell. 2007 Dec 14;131(6):1084-96. doi: 10.1016/j.cell.2007.09.046.
2
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.三甲基化组蛋白H3赖氨酸4的识别有助于转录起始后因子的募集和前体mRNA剪接。
Mol Cell. 2007 Nov 30;28(4):665-76. doi: 10.1016/j.molcel.2007.11.010.
3
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Nature. 2007 Dec 13;450(7172):1106-10. doi: 10.1038/nature06431. Epub 2007 Nov 21.
4
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.重组激活基因2（RAG2）的植物同源结构域指识别在赖氨酸-4和精氨酸-2处均发生甲基化的组蛋白H3。
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18993-8. doi: 10.1073/pnas.0709170104. Epub 2007 Nov 19.
5
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Cell. 2007 Nov 16;131(4):633-6. doi: 10.1016/j.cell.2007.10.039.
6
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Nat Genet. 2007 Dec;39(12):1512-6. doi: 10.1038/ng.2007.26. Epub 2007 Nov 11.
7
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8
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9
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Nature. 2007 Oct 18;449(7164):933-7. doi: 10.1038/nature06166. Epub 2007 Sep 26.
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Cell. 2007 Oct 5;131(1):58-69. doi: 10.1016/j.cell.2007.08.016. Epub 2007 Sep 20.
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