Shemanko Carrie S
Department of Biological Sciences and the Southern Alberta Cancer Research Institute, University of Calgary, 2500 University Dr. NW, Calgary, Alberta, T2N 1N4, Canada.
Front Biosci. 2008 May 1;13:3940-50. doi: 10.2741/2982.
Prolactin is a pleiotropic peptide hormone and cytokine that is secreted from the pituitary gland and locally within various tissues of the body for autocrine and paracrine signal transduction. It controls proliferation and differentiation in a number of body tissues and increasing evidence indicates that it controls these functions in undifferentiated stem and progenitor cells of adult tissues, such as mesenchymal stem cells, hematopoietic progenitors, neural stem cells, oligodendrocyte precursor cells and possibly in mammary gland stem/progenitor cells. These roles in these undifferentiated cell types also implicate prolactin in the stem cell theory of cancer, supporting its known roles in cancer formation and progression.
催乳素是一种具有多效性的肽类激素和细胞因子，由垂体分泌，并在身体的各种组织中局部分泌，用于自分泌和旁分泌信号转导。它控制着许多身体组织中的细胞增殖和分化，越来越多的证据表明，它在成体组织的未分化干细胞和祖细胞中发挥这些功能，如间充质干细胞、造血祖细胞、神经干细胞、少突胶质细胞前体细胞，可能还有乳腺干细胞/祖细胞。催乳素在这些未分化细胞类型中的这些作用也表明其与癌症的干细胞理论有关，支持了其在癌症形成和进展中已知的作用。
