Goldman David L, Casadevall Arturo
Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Front Biosci. 2008 May 1;13:4009-14. doi: 10.2741/2988.
Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.
近期事件已使人们关注到炭疽芽孢杆菌作为生物恐怖主义制剂的潜在威胁。尽管进行了抗菌治疗和支持性治疗，但炭疽所致的休克样状态总是与高死亡率相关。多系统功能障碍很典型，包括：血管通透性增强、出血和炎症。关于炭疽相关休克病理生理学的重要问题仍未得到解答，包括炭疽芽孢杆菌感染对心脏功能的影响。本综述讨论了关于炭疽相关休克病理生理学的当前知识状况。
