Fanton J W, Golden J G
Veterinary Sciences Division, USAF School of Aerospace Medicine, Brooks AFB, Texas 78235.
Radiat Res. 1991 May;126(2):141-6.
Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (chi 2, P less than 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidence of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.
雌性恒河猴接受了单能质子、混合能质子、X射线和电子形式的全身电离辐射剂量。在暴露后的17年期间，53%的猴子患上了子宫内膜异位症。与辐射类型相关的子宫内膜异位症发病率分别为：单能质子，54%；混合能质子，73%；X射线，71%；电子，57%。未接受辐射的对照猴子中子宫内膜异位症的发病率为26%。暴露于单能质子、混合能质子和X射线的猴子患子宫内膜异位症的比率明显高于对照猴子（卡方检验，P<0.05）。子宫内膜异位症的严重程度分为重度、中度和轻度。这些阶段的发病率分别为65%、16%和19%。临床疾病观察包括43%的猴子体重减轻，35%的猴子食欲不振，55%的猴子通过腹部触诊发现占位性肿块，89%的猴子直肠检查发现卵巢/子宫解剖结构异常，38%的猴子有腹部肿块的影像学证据。病理病变包括69%的猴子出现子宫内膜囊肿形成，66%的猴子结肠粘连，50%的猴子膀胱粘连，86%的猴子卵巢粘连，44%的猴子输尿管粘连，59%的猴子大网膜有散在的子宫内膜组织结节，9%的猴子有转移。子宫内膜异位症的临床治疗包括减瘤手术和双侧输卵管卵巢切除术，在某些情况下还结合全腹子宫切除术。从手术中恢复的猴子术后1年和5年的生存率分别为48%和36%。
