Liang Han, Fernandez Ariel
Department of Ecology and Evolution, University of Chicago, IL 60637, USA.
Front Biosci. 2008 May 1;13:4373-8. doi: 10.2741/3010.
The gene dosage balance hypothesis states that a concentration imbalance among components of macromolecules is often deleterious. Thus this notion potentially provides a mechanistic explanation for understanding genetic dominance and gene duplicability. Accumulating evidence emerged from recent genomic data has strongly supported this hypothesis. Further efforts are needed to understand dosage sensitivity in the context of organismal complexity and co-regulation of genes under dosage-balance constraints.
基因剂量平衡假说指出，大分子各组分之间的浓度失衡通常是有害的。因此，这一概念可能为理解遗传显性和基因可复制性提供一种机制性解释。最近基因组数据中出现的越来越多的证据有力地支持了这一假说。需要进一步努力，以便在生物体复杂性以及剂量平衡限制下基因的共同调控背景下理解剂量敏感性。
