Waugh David J J, Wilson Catherine, Seaton Angela, Maxwell Pamela J
Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL.
Front Biosci. 2008 May 1;13:4595-604. doi: 10.2741/3025.
CXC-chemokines play an essential role in co-ordinating the function of the immune system. Increasingly, these small signaling molecules are recognized in facilitating communication between multiple cell types within the tumor microenvironment. This review will summarize the role of two members of this family, CXCL12 (stromal cell derived factor-1) and CXCL8 (interleukin-8) in promoting the disease progression of prostate cancer, the most prevalent non-cutaneous cancer in men in western society and the second leading cause of death from cancer in men. Evidence for a role of these chemokines in underpinning the development and progression of this disease is supported by examination of prostate tissue and serum samples from prostate cancer patients, from biochemical and molecular investigations conducted on representative cell-based models of this disease and from observation of CXC-chemokine promoted growth and systemic dissemination of human prostate tumors in experimental in vivo models. The future potential of employing strategies to attenuate chemokine expression or alternatively to selectively block chemokine receptor signaling to effect greater long-term control or enhanced therapeutic response in this disease is also discussed.
CXC趋化因子在协调免疫系统功能方面发挥着至关重要的作用。这些小信号分子在促进肿瘤微环境中多种细胞类型之间的通讯方面越来越受到认可。本综述将总结该家族的两个成员CXCL12（基质细胞衍生因子-1）和CXCL8（白细胞介素-8）在促进前列腺癌疾病进展中的作用，前列腺癌是西方社会男性中最常见的非皮肤癌，也是男性癌症死亡的第二大主要原因。通过对前列腺癌患者的前列腺组织和血清样本进行检查、对该疾病具有代表性的细胞模型进行生化和分子研究以及在实验性体内模型中观察CXC趋化因子促进人前列腺肿瘤的生长和全身扩散，支持了这些趋化因子在支持该疾病的发生和发展中发挥作用的证据。本文还讨论了采用策略减弱趋化因子表达或选择性阻断趋化因子受体信号传导以实现对该疾病更长期控制或增强治疗反应的未来潜力。
