Mills Ken
CCRCB, Queen's University Belfast, Lisburn Road, Belfast, UK. BT9 7BL.
Front Biosci. 2008 May 1;13:4605-16. doi: 10.2741/3026.
Acute myeloid leukaemia (AML) is a heterogeneous disease covering a range of morphological lineages and differentiation stages, but also has number of recurrent chromosomal abnormalities and mutations associated with prognosis. Because of the defined molecular and cytogenetic features, AML has been a focus of gene expression profiling studies and identified differentially expressed genes in the different diagnostic and cytogenetic sub-groups. These studies have lead to the development of expression based classifications and diagnostic chips with further studies aiding prognosis and therapeutic choices.
急性髓系白血病（AML）是一种异质性疾病，涵盖一系列形态学谱系和分化阶段，同时还存在许多与预后相关的复发性染色体异常和突变。由于具有明确的分子和细胞遗传学特征，AML一直是基因表达谱研究的重点，并已在不同诊断和细胞遗传学亚组中鉴定出差异表达基因。这些研究促成了基于表达的分类和诊断芯片的发展，进一步的研究有助于预后评估和治疗选择。
