Włodarczyk Janusz
Oddział Chirurgii Klatki Piersiowej Krakowski Szpital Specjalistyczny im. Jana Pawła II.
Przegl Lek. 2007;64(9):549-51.
Endoscopy examination followed by Lugol solution staining is used in the diagnostics of early squamous cell carcinoma of the esophagus. The aim of the study was to describe usage of this method for the assessment of effectiveness in the gastroesophageal reflux disease. The method uses reaction between glycogen, present in epithelium, and iodine in Lugol solution. The study was conducted in 98 patients. Endoscopic assessment was made before application of Lugol solution, subsequently the gastroesophageal borderline and staining of mucosa membrane after application of Lugol solution was assessed. Biopsies were taken from the stained and unstained areas. The performed study showed that sensitivity of the method is 84%, specificity 79% and effectiveness 85%. The ratio of stained and unstained areas is statistically typical p=0.045.
Endoscopic examination followed by Lugol solution staining are sensitive diagnostic methods in the gastroesophageal reflux disease. It is a simple and quick method which should be widely applied.
内镜检查后进行卢戈氏液染色用于早期食管鳞状细胞癌的诊断。本研究的目的是描述该方法在评估胃食管反流病有效性方面的应用。该方法利用上皮细胞中存在的糖原与卢戈氏液中的碘之间的反应。研究共纳入98例患者。在应用卢戈氏液之前进行内镜评估，随后评估应用卢戈氏液后的胃食管交界及黏膜染色情况。从染色和未染色区域取活检组织。所进行的研究表明，该方法的敏感性为84%，特异性为79%，有效性为85%。染色区与未染色区的比例具有统计学意义，p = 0.045。
内镜检查后进行卢戈氏液染色是胃食管反流病敏感的诊断方法。这是一种简单快速的方法，应广泛应用。
