Weissman A D, Casanova M F, Kleinman J E, De Souza E B
Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224.
Neuropsychopharmacology. 1991 Feb;4(2):95-102.
The psychotomimetic effects of phencyclidine (PCP) in humans can persist or reappear months after the drug has been eliminated, suggesting that PCP can induce long-term changes in the brain. The present study examined whether repeated exposure to PCP in a human drug-addicted population was accompanied by alterations in either PCP or sigma binding sites in their postmortem brains as compared to suicide controls. Saturation studies using [3H]TCP and [3H]haloperidol in the presence of spiperone to measure PCP and sigma sites, respectively, revealed no significant differences in the affinity or density of binding sites between these two clinical populations in a variety of brain areas examined. The results suggest that these brain binding sites remain unperturbed in humans despite multiple challenges with PCP. Delayed psychotic episodes following the use of PCP may be attributed to other neurochemical changes that are initiated by interactions of PCP with these two binding sites.
苯环利定（PCP）对人类的拟精神病作用在药物消除数月后仍可能持续或再次出现，这表明PCP可诱导大脑发生长期变化。本研究调查了与自杀对照组相比，在人类吸毒成瘾人群中反复接触PCP是否伴随着其死后大脑中PCP或西格玛结合位点的改变。分别使用[3H]TCP和[3H]氟哌啶醇在螺哌隆存在的情况下进行饱和研究以测量PCP和西格玛位点，结果显示在检查的多个脑区中，这两个临床人群之间结合位点的亲和力或密度没有显著差异。结果表明，尽管多次接触PCP，但人类大脑中的这些结合位点并未受到干扰。使用PCP后出现的延迟性精神病发作可能归因于PCP与这两个结合位点相互作用引发的其他神经化学变化。
