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老年患者的肾脏手术:当代系列研究中75岁以上患者的发病率

Renal surgery in the elderly: morbidity in patients aged >75 years in a contemporary series.

作者信息

Staehler Michael, Haseke Nicolas, Stadler Thomas, Bader Markus, Karl Alexander, Becker Armin, Stief Christian G

机构信息

Department of Urology, University of Munich, Klinikum Grosshadern, München, Germany.

出版信息

BJU Int. 2008 Sep;102(6):684-7. doi: 10.1111/j.1464-410X.2008.07794.x. Epub 2008 May 26.

DOI:10.1111/j.1464-410X.2008.07794.x
PMID:18510657
Abstract

OBJECTIVES

To evaluate the surgical complications in a contemporary group of elderly patients with renal masses, as almost a quarter of patients with newly diagnosed renal mass are aged >74 years, with the potential for significant comorbidity.

PATIENTS AND METHODS

From April 2004 to June 2007, of 379 surgical resections of renal tumours, we assessed 117 consecutive patients aged >or=75 years, who had either radical nephrectomy (RN) or partial nephrectomy (PN) for assumed renal cell carcinoma. Also elderly patients who had nephroureterectomy (NU) for upper urothelial cancer were followed.

RESULTS

Fifty patients had RN, 57 PN and 10 had NU; the median (range) age of all patients was 78.1 (72.7-92.5) years and was similar in all groups. No patient died during surgery and only one died within 90 days. The complication rates during and after surgery RN, PN and NU were 12%, 15% and 20%, respectively; the major complications within 30 days were 4%, 7% and 10%; major complications included bleeding during surgery and one acute bleeding event after surgery in the PN group.

CONCLUSIONS

Open renal surgery in elderly patients can be done safely; there was no difference in morbidity among RN, PN and NU. Renal surgery in the elderly patient is safe if done at a specialized centre. Mortality and morbidity can be very low, rendering this a feasible approach in the treatment of renal masses even if the prognosis is not determined by the oncological situation but by comorbidity.

摘要

目的

评估当代一组老年肾肿块患者的手术并发症,因为新诊断的肾肿块患者中近四分之一年龄超过74岁,且可能存在显著的合并症。

患者与方法

2004年4月至2007年6月,在379例肾肿瘤手术切除病例中,我们评估了117例年龄≥75岁的连续患者,这些患者因疑似肾细胞癌接受了根治性肾切除术(RN)或部分肾切除术(PN)。同时对因上尿路尿路上皮癌接受肾输尿管切除术(NU)的老年患者进行了随访。

结果

50例患者接受了RN,57例接受了PN,10例接受了NU;所有患者的中位(范围)年龄为78.1(72.7 - 92.5)岁,各组相似。无患者在手术期间死亡,仅1例在90天内死亡。RN、PN和NU手术期间及术后的并发症发生率分别为12%、15%和20%;30天内的主要并发症发生率分别为4%、7%和10%;主要并发症包括手术期间出血以及PN组术后1例急性出血事件。

结论

老年患者的开放性肾手术可以安全进行;RN、PN和NU之间的发病率无差异。如果在专业中心进行,老年患者的肾手术是安全的。死亡率和发病率可能非常低,即使预后不是由肿瘤情况决定而是由合并症决定,这也使肾肿块的治疗成为一种可行的方法。

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