Sampaio-Sa Marcia, Page-Shafer Kimberly, Bangsberg David R, Evans Jennifer, Dourado Maria de Lourdes, Teixeira Celia, Netto Eduardo M, Brites Carlos
Federal University of Bahia, Salvador, Bahia, Brazil.
AIDS Behav. 2008 Jul;12(4 Suppl):S54-62. doi: 10.1007/s10461-008-9414-0. Epub 2008 May 30.
We conducted a randomized trial to test an intervention aimed at increasing adherence to antiretroviral therapy (ART) among HIV-positive, ART-naïve patients in Salvador, Brazil. Participants (N = 107) were randomized to either educational workshops based on the information-motivation-behavioral skills model (n = 52) or a control video session (n = 55). Changes in self-reported ART adherence, viral load, CD4 cell counts and ART pharmacy records were measured periodically over 12 months. After 3-6 months, ART adherence (> or = 95%) was 77.8% in the workshop group and 85.7% in video group (as treated) and 53.8% and 65.5%, respectively, using intention-to-treat (ITT) analysis (both P > 0.05) At 9-12 months, ART adherence decreased to 73.7% in the workshop group and 79.1% in the video group (as treated) and 53.8% and 61.8% using ITT, respectively. No differences were found in self-reported adherence, viral load or pharmacy records between groups. We found that the educational workshop intervention does not increase adherence to ART.
我们开展了一项随机试验，以测试一项干预措施，该措施旨在提高巴西萨尔瓦多未接受过抗逆转录病毒治疗（ART）的HIV阳性患者对ART的依从性。参与者（N = 107）被随机分为基于信息-动机-行为技能模型的教育工作坊组（n = 52）或对照视频组（n = 55）。在12个月内定期测量自我报告的ART依从性、病毒载量、CD4细胞计数和ART药房记录的变化。3至6个月后，使用意向性分析（ITT），工作坊组的ART依从性（≥95%）为77.8%，视频组为85.7%（实际治疗情况），ITT分析结果分别为53.8%和65.5%（均P>0.05）。在9至12个月时，工作坊组的ART依从性降至73.7%，视频组降至79.1%（实际治疗情况），ITT分析结果分别为53.8%和61.8%。两组之间在自我报告的依从性、病毒载量或药房记录方面未发现差异。我们发现，教育工作坊干预措施并未提高对ART的依从性。
