由于组织金属蛋白酶抑制剂（TIMP）表达降低，转移细胞中的胶原酶活性增加。
Increased collagenase activity in metastatic cells as a result of decreased TIMP expression.
作者信息
Skup D, Ponton A
机构信息
l'Institut du cancer de Montréal, PQ, Canada.
出版信息
J Rheumatol Suppl. 1991 Feb;27:92-4.
PMID:1851232
Abstract
It has been postulated in a number of systems that increased metalloproteinase activity in different pathologies can be due to decreased levels of the specific inhibitor tissue inhibitor of metalloproteinases (TIMP). To date direct proof of such a mechanism has been lacking. We report that in metastatic variants which secrete increased levels of collagenase activity, this is due to decreased levels of TIMP activity and mRNA levels.
摘要
在许多系统中都有这样的推测，即在不同病理状态下金属蛋白酶活性增加可能是由于金属蛋白酶特异性抑制剂——金属蛋白酶组织抑制剂（TIMP）水平降低所致。迄今为止，尚无这种机制的直接证据。我们报告，在分泌胶原酶活性水平增加的转移变体中，这是由于TIMP活性和mRNA水平降低所致。
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