Webb-Johnson D C
Geriatrics. 1976 Nov;31(11):79-87.
The development of effective drugs for chronic lung disease, especially bronchodilator aerosols, has been a boon to patients and physicians alike, but these agents also may provoke arrhythmias. Fluorocarbon propellants, once regarded as harmless, are now known to disrupt cardiac function, sensitizing the heart to the arrhythmic effects of sympathomimetic amines. Catecholamine drugs as a group have a strong impact on heart rate and contractility. But the danger of rhythm disturbances often can be reduced by cutting the dosage or choosing a preparation with more beta 2 activity. Methylxanthines, generally safer than catecholamines, nevertheless must be used with caution and preferably alone in patients with heart and lung disease.
开发治疗慢性肺病的有效药物，尤其是支气管扩张气雾剂，对患者和医生来说都是福音，但这些药物也可能引发心律失常。氟碳推进剂曾被认为是无害的，现在已知会扰乱心脏功能，使心脏对拟交感胺的心律失常作用敏感。儿茶酚胺类药物总体上对心率和收缩力有强烈影响。但通过减少剂量或选择具有更多β2活性的制剂，通常可以降低节律紊乱的风险。甲基黄嘌呤通常比儿茶酚胺更安全，但在患有心肺疾病的患者中仍必须谨慎使用，最好单独使用。
