Valkovic Peter, Brozová Hana, Bötzel Kai, Růzicka Evzen, Benetin Ján
2nd Department of Neurology, School of Medicine, Comenius University, Bratislava, Slovak Republic.
Mov Disord. 2008 Jul 30;23(10):1453-7. doi: 10.1002/mds.22131.
The aim of this study was to compare the Pull Test--Retropulsion Test and the Push and Release Test (P&R) as regards their ability to predict Parkinson (PD) fallers and nonfallers in relation to their medication state. Eighty-two PD patients participated in the study. Fallers (N = 36) and nonfallers (N = 46) were grouped on the basis of their fall history. Fallers were those who had fallen at least once within the last 6 months. The two groups were compared on the basis of the patients' performance in the Pull and the P&R tests, both in their "OFF" and "ON" medication state. The overall accuracy of the classification of PD patients as fallers and nonfallers was determined by means of binomial logistic regression (BLR) and the analysis of the "area under the receiver operating characteristics curve" (AUC). In the OFF medication state, the statistical analysis revealed that the Pull Test was accurate (methods BLR (AUC)) in 85.4% (0.87) of cases and the P&R Test in 86.6% (0.90). In the ON medication state, the Pull Test was only 76.8% (0.78) accurate, while the P&R Test was 87.8% (0.87) accurate. Both clinical tests are valid and relatively equivalent when assessing patients in their OFF medication state; however, the P&R Test is more accurate than the Pull Test in the ON state. This indicates that it is more widely applicable in clinical practice.
本研究的目的是比较拉力试验-后推试验与推放试验(P&R)在根据帕金森病(PD)患者的用药状态预测其跌倒者和非跌倒者方面的能力。82名PD患者参与了本研究。跌倒者(N = 36)和非跌倒者(N = 46)根据其跌倒史进行分组。跌倒者是指在过去6个月内至少跌倒过一次的患者。在患者处于“关”和“开”药状态下,根据其在拉力试验和P&R试验中的表现对两组进行比较。通过二项逻辑回归(BLR)和“受试者工作特征曲线下面积”(AUC)分析来确定将PD患者分类为跌倒者和非跌倒者的总体准确性。在关药状态下,统计分析显示拉力试验在85.4%(0.87)的病例中准确(方法BLR(AUC)),P&R试验在86.6%(0.90)的病例中准确。在开药状态下,拉力试验的准确率仅为76.8%(0.78),而P&R试验的准确率为87.8%(0.87)。在评估处于关药状态的患者时,这两种临床试验都是有效的且相对等效;然而,在开药状态下,P&R试验比拉力试验更准确。这表明它在临床实践中更广泛适用。