Frappaz D, Elian J C, Brunon J, Freycon F
Laboratoire de culture cellulaire à moyen terme, faculté de médecine de St-Etienne, St-Etienne, France.
Pediatrie. 1991;46(1):59-64.
Glioblastomas and medulloblastomas are models for studying the implication of growth factors and oncogenes in tumor development. Amplification and/or hyperexpression of oncogenes result in products that may mimic growth factors and/or their receptors; cells may demonstrate autocrine and/or paracrine activity. Prognostic implications of such findings are suggested.
胶质母细胞瘤和髓母细胞瘤是研究生长因子和癌基因在肿瘤发展中作用的模型。癌基因的扩增和/或过度表达会产生可能模拟生长因子和/或其受体的产物；细胞可能表现出自分泌和/或旁分泌活性。这些发现的预后意义也得到了提示。
