Yi Gui-Wen, Zeng Qiu-Tang
Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
Arch Med Res. 2008 Jul;39(5):531-5. doi: 10.1016/j.arcmed.2008.04.003.
The novel chemokine CXCL16 is involved in the development of atherosclerosis and coronary artery disease (CAD). However, the role of CXCL16 in atherosclerosis remains uncertain. This study was designed to investigate the relationship between CXCL16 and the severity of coronary artery stenosis.
Using ELISA, we assayed the plasma CXCL16 concentration in 16 stable angina pectoris (SAP) patients, 53 acute coronary syndrome (ACS) patients, and 19 control patients. All patients underwent coronary angiography after admission. They were divided into four groups according to the quartile of CXCL16 level. Characteristics and the relationship between CXCL16 and the elements were studied in each group.
CXCL16 levels in the ACS group were higher than controls and SAP group (p <0.01 vs. controls; p <0.05 vs. SAP group). Gensini score in the highest quartile group of CXCL16 level (group IV, CXCL16 >2.21 ng/mL) was significantly higher than in the lowest quartile group of CXCL16 level (group I, CXCL16 < or = 1.43 ng/mL) (p <0.001). Gensini score in group II (1.43 ng/mL <CXCL16 < or = 1.72 ng/mL) and group III (1.72 ng/mL<CXCL16 < or = 2.21 ng/mL) were also higher than in group I (p <0.05, p <0.01). In addition, CXCL16 level had a positive correlation with Gensini score (r = 0.519, p <0.001).
CXCL16 levels are positively associated with the severity of coronary artery stenosis. Activity level of CXCL16 in human plasma appears to be a good biomarker for epidemiological and clinical application in CAD.
新型趋化因子CXCL16参与动脉粥样硬化和冠状动脉疾病（CAD）的发展。然而，CXCL16在动脉粥样硬化中的作用仍不明确。本研究旨在探讨CXCL16与冠状动脉狭窄严重程度之间的关系。
采用酶联免疫吸附测定法（ELISA），检测16例稳定型心绞痛（SAP）患者、53例急性冠状动脉综合征（ACS）患者和19例对照患者血浆CXCL16浓度。所有患者入院后均接受冠状动脉造影检查。根据CXCL16水平的四分位数将他们分为四组。研究每组的特征以及CXCL16与各因素之间的关系。
ACS组CXCL16水平高于对照组和SAP组（与对照组相比，p<0.01；与SAP组相比，p<0.05）。CXCL16水平最高四分位数组（第四组，CXCL16>2.21 ng/mL）的Gensini评分显著高于CXCL16水平最低四分位数组（第一组，CXCL16≤1.43 ng/mL）（p<0.001）。第二组（1.43 ng/mL<CXCL16≤1.72 ng/mL）和第三组（1.72 ng/mL<CXCL16≤2.21 ng/mL）的Gensini评分也高于第一组（p<0.05，p<0.01）。此外，CXCL16水平与Gensini评分呈正相关（r = 0.519，p<0.
