转移性肉瘤的多学科管理

Multidisciplinary management of metastatic sarcoma.

作者信息

Thornton Katherine, Pesce Catherine E, Choti Michael A

机构信息

Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

出版信息

Surg Clin North Am. 2008 Jun;88(3):661-72, viii. doi: 10.1016/j.suc.2008.04.002.

DOI:10.1016/j.suc.2008.04.002

PMID:18514705

Abstract

Soft tissue sarcomas comprise a heterogeneous group of malignancies of mesenchymal origin. Although sarcomas can arise virtually anywhere, the most common primary site is the extremity. The development of metastatic disease poses a major clinical problem because it is seldom amenable to a curative treatment. However, with careful and expert multidisciplinary team selection of patients with metastatic sarcoma-balancing probability of benefit with certain toxicity-a combined multimodality approach may provide hope to a select few for prolonged survival and even cure.

摘要

软组织肉瘤是一组异质性的间充质来源恶性肿瘤。虽然肉瘤实际上可发生于任何部位，但最常见的原发部位是四肢。转移性疾病的发生构成了一个重大临床问题，因为它很少能通过根治性治疗治愈。然而，通过仔细且专业的多学科团队为转移性肉瘤患者进行筛选——权衡获益可能性与特定毒性——联合多模式治疗方法可能会给少数患者带来延长生存期甚至治愈的希望。