Laatikainen T, Virtanen T, Kaaja R, Salminen-Lappalainen K
Department I, of Obstetrics and Gynecology, University of Helsinki, Finland.
Eur J Obstet Gynecol Reprod Biol. 1991 Mar 21;39(1):19-24. doi: 10.1016/0028-2243(91)90136-9.
The concentration of corticotropin-releasing hormone (CRH) in maternal plasma increases greatly during the last trimester of normal pregnancy. This CRH has been proposed to originate from the placenta. We studied plasma immunoreactive CRH in 46 uncomplicated pregnancies, in 10 pregnant women with chronic hypertension, in 17 women with pregnancy-induced hypertension (PIH) and in 24 women with pre-eclampsia, and correlated it to the levels of corticotropin (ACTH) and cortisol. CRH levels were greatly increased in women with pre-eclampsia, less significantly in women with PIH, while no change was found in pregnant women with chronic hypertension. ACTH levels also were increased in pregnancies with pre-eclampsia or PIH and there was a positive correlation between CRH and ACTH levels. CRH levels in cord venous plasma were significantly increased in pregnancies with pre-eclampsia but cortisol did not show any significant increase. These findings suggest that placental release of CRH into the maternal and fetal circulation is increased in pre-eclampsia.
在正常妊娠的最后三个月，母体血浆中促肾上腺皮质激素释放激素（CRH）的浓度大幅增加。有人提出这种CRH源自胎盘。我们研究了46例无并发症妊娠、10例慢性高血压孕妇、17例妊娠高血压综合征（PIH）孕妇和24例先兆子痫孕妇的血浆免疫反应性CRH，并将其与促肾上腺皮质激素（ACTH）和皮质醇水平进行关联。先兆子痫女性的CRH水平大幅升高，PIH女性的升高不太显著，而慢性高血压孕妇未发现变化。先兆子痫或PIH妊娠的ACTH水平也升高，且CRH与ACTH水平呈正相关。先兆子痫妊娠的脐静脉血浆中CRH水平显著升高，但皮质醇未显示任何显著增加。这些发现表明，先兆子痫时胎盘向母体和胎儿循环释放CRH增加。
