Francini-Pesenti F, Brocadello F, Beltramolli D, Nardi M, Caregaro L
Clinical Nutrition Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera, via Giustiniani 2, 35100 Padua, Italy.
Complement Ther Med. 2008 Apr;16(2):61-5. doi: 10.1016/j.ctim.2007.08.003. Epub 2008 Jan 18.
Previous clinical studies have shown that oral administration of sugar cane policosanol (SCP) reduces plasma total cholesterol and low-density lipoprotein cholesterol levels. A double blind, randomized, placebo controlled trial was performed in hypercholesterolaemic, diet-resistant patients. Seventy patients meeting the selection criteria were enrolled. Each subject was treated with policosanol 10 mg/d in addition to a dietetic regimen for 8 weeks. At the start and at the end of the study body weight, body mass index (BMI), total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides (TG) plasma levels were measured. Thirty-three subjects in the policosanol and Thirty-one subjects in the control group completed the study. During the study body mass index, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides plasma levels did not change significantly within and between groups. In conclusion, sugar cane policosanol at a dose of 10mg/d showed no lipid lowering effects in subjects with primitive, diet-resistant hypercholesterolaemia.
先前的临床研究表明，口服甘蔗多廿烷醇（SCP）可降低血浆总胆固醇和低密度脂蛋白胆固醇水平。对饮食控制无效的高胆固醇血症患者进行了一项双盲、随机、安慰剂对照试验。招募了70名符合入选标准的患者。除饮食方案外，每位受试者接受10mg/d多廿烷醇治疗，为期8周。在研究开始和结束时，测量体重、体重指数（BMI）、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯（TG）的血浆水平。多廿烷醇组的33名受试者和对照组的31名受试者完成了研究。在研究期间，体重指数、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯的血浆水平在组内和组间均无显著变化。总之，对于原发性、饮食控制无效的高胆固醇血症患者，10mg/d的甘蔗多廿烷醇未显示出降脂作用。
