青少年使用大麻与精神病前驱症状的关联。
Association of cannabis use with prodromal symptoms of psychosis in adolescence.
作者信息
Miettunen Jouko, Törmänen Sari, Murray Graham K, Jones Peter B, Mäki Pirjo, Ebeling Hanna, Moilanen Irma, Taanila Anja, Heinimaa Markus, Joukamaa Matti, Veijola Juha
机构信息
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland.
出版信息
Br J Psychiatry. 2008 Jun;192(6):470-1. doi: 10.1192/bjp.bp.107.045740.
Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.
最近，人们的兴趣集中在大麻使用与精神病风险之间的关联上。在迄今为止关于该主题的最大规模、基于人群的非选择性研究中，我们调查了6330名青少年在15 - 16岁时的大麻使用情况和精神病前驱症状。那些尝试过大麻的人（n = 352；占总样本的5.6%）即使在控制了包括先前行为症状在内的混杂因素后，也更有可能出现三种或更多的前驱症状（OR = 2.23；95% CI 1.70 - 2.94）。观察到了剂量反应效应。我们得出结论，大麻使用与青少年精神病前驱症状有关。
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